Thomas Seidel

Thomas Seidel studied Technical Chemistry at the Vienna University of Technology where he received a PhD in Synthetic Organic Chemistry in 2003. From 2004 until 2005 he worked as a postdoctoral research assistant in the group of Prof. Johann Gasteiger at the Computer Chemistry Center/University of Erlangen-Nuremberg. The main focus of his research was the development of methods and algorithms to assess the synthetic accessibility of compounds generated by de novo design. After his postdoctoral stay he returned to Vienna for a position at the company InteLigand GmbH where he developed cheminformatics software for pharmacophore modeling and virtual screening. Since 2014 Thomas Seidel is a senior PostDoc at the Department of Pharmaceutical Chemistry/University of Vienna where he leads the chemoinformatics research group. The main topics of his research are the development and implementation of novel algorithms for pharmacophore-based drug development, the advancement of the pharmacophore concept and the application of molecular dynamics simulations and machine learning methods in the context of molecular design.

Contact
E-Mail: thomas.seidel@univie.ac.at
Tel: +43-1-4277-55051
Room: 2E 354
Publications: u:cris

Wieder M, Perricone U, Seidel T , Langer T. Pharmacophore models derived from molecular dynamics simulations of protein-ligand complexes: A case study. Natural Product Communications. 2016 Oct;11(10):1499-1504. doi: 10.1177/1934578x1601101019

Wieder M, Perricone U, Seidel T , Boresch S , Langer T. Comparing pharmacophore models derived from crystal structures and from molecular dynamics simulations. Monatshefte für Chemie. 2016 Mar;147(3):553-563. doi: 10.1007/s00706-016-1674-1

Wieder M, Perricone U, Boresch S , Seidel T , Langer T. Evaluating the stability of pharmacophore features using molecular dynamics simulations. Biochemical and Biophysical Research Communications. 2016 Feb 12;470(3):685-689. doi: 10.1016/j.bbrc.2016.01.081

Luger D, Poli G, Wieder M, Stadler M, Ke S, Ernst M et al. Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis. British Journal of Pharmacology. 2015 Nov;172(22):5403-5413. doi: 10.1111/bph.13329, 10.1111/bph.13329

Seidel T, Ibis G, Bendix F, Wolber G. Strategies for 3D pharmacophore-based virtual screening. Drug Discovery Today: Technologies. 2010;7(4):e221-e228. doi: 10.1016/j.ddtec.2010.11.004

Seidel T, Wolber G, Langer T. CINF 59-Ligand tautomer enumeration and scoring for structure-based 3-D pharmacophore modeling. American Chemical Society. Abstracts of Papers (at the National Meeting). 2008 Aug 17;236.

Wolber G, Seidel T, Bendix F, Langer T. Molecule-pharmacophore superpositioning and pattern matching in computational drug design. Drug Discovery Today. 2008 Jan;13(1-2):23-29.

Dipl.-Ing. Dr. Thomas Seidel

Dipl.-Ing. Dr. Thomas Seidel